COVID-19: DEXAMETHASONE DISCOVERY CARRIES TREATMENT IMPLICATIONS

--References publication:  Molecular determinants of vascular transport of dexamethasone in COVID-19 therapy..  Shabalin IG, Czub MP, Majorek KA, Brzezinski D, Grabowski M, Cooper DR, Panasiuk M, Chruszcz M, Minor W.  IUCrJ   [Pub Med ID: 33063792]   [Pub Med Central ID: PMC7553145] [DOI:10.1107/S2052252520012944]

--References structures:  6XK0

COVID-19 Structure Analysis Tool

As part of an international collaboration, the lab has created a tool allowing scientists to quickly see the progress of the structural biology community pertaining to SARS-CoV-2, the COVID-19 virus.

--References publication:  Covid-19.bioreproducibility.org: A web resource for SARS-CoV-2-related structural models..  Brzezinski D, Kowiel M, Cooper DR, Cymborowski M, Grabowski M, Wlodawer A, Dauter Z, Shabalin IG, Gilski M, Rupp B, Jaskolski M, Minor W.  Protein Sci   30:115-124   [Pub Med ID: 32981130]   [Pub Med Central ID: PMC7537053] [DOI:10.1002/pro.3959]

--References publication:  Ligand-centered assessment of SARS-CoV-2 drug target models in the Protein Data Bank..  Wlodawer A, Dauter Z, Shabalin IG, Gilski M, Brzezinski D, Kowiel M, Minor W, Rupp B, Jaskolski M.  FEBS J   287:3703-3718   [Pub Med ID: 32418327]   [Pub Med Central ID: PMC7276724] [DOI:10.1111/febs.15366]


Wladek Minor interviewed at UNIVPM BigDat2020

At Università Politecnica delle Marche

Albumin / Testosterone Discovery

Our recent structures reveal that testosterone binds to serum albumin in two unpredicted spots. Some other drugs and hormones, including some involved in diabetes, utilize these same sites.

--References publication:  Testosterone meets albumin - the molecular mechanism of sex hormone transport by serum albumins..  Czub MP, Venkataramany BS, Majorek KA, Handing KB, Porebski PJ, Beeram SR, Suh K, Woolfork AG, Hage DS, Shabalin IG, Minor W.  Chem Sci   10:1607-1618   [Pub Med ID: 30842823]   [Pub Med Central ID: PMC6371759] [DOI:10.1039/c8sc04397c]

--References structures:  6MDQ

Wladek Minor Elected AAAS Fellow

The American Association for the Advancement of Science has elected Dr. Minor to the rank of Fellow for his "distinguished contributions in structural biology."

University of Warsaw - American Friends of UW joint award given to Wladek Minor

The American Friends of the University of Warsaw presented Dr. Minor with the award on November 30 at the residence of the Polish Ambassador in Washington.

Wladek Minor Elected American Crystallographic Association Fellow

Raw experimental data for 3D structures highlighted at PDBe

The PDBe now has a "Experimental raw data" widget on structure pages to provide a direct link to raw diffraction data stored at the IIRMC (ProteinDiffraction.org).

A New Guide for Explorers of the Submicroscopic World Inside Us

--References publication:  Characterizing metal-binding sites in proteins with X-ray crystallography..  Handing KB, Niedzialkowska E, Shabalin IG, Kuhn ML, Zheng H, Minor W.  Nat Protoc   13:1062-1090   [Pub Med ID: 29674755]   [Pub Med Central ID: PMC6235626] [DOI:10.1038/nprot.2018.018]


Wladek Minor Polish Radio Interview

Broadcast in multiple places in Poland (in Polish)

New Distinguished Research Service Award for Lab Alumni Maks Chruszcz

Must Life be Carbon-Based?

A public database of macromolecular diffraction experiments

--References publication:  A public database of macromolecular diffraction experiments..  Grabowski M, Langner KM, Cymborowski M, Porebski PJ, Sroka P, Zheng H, Cooper DR, Zimmerman MD, Elsliger MA, Burley SK, Minor W.  Acta Crystallogr D Struct Biol   72:1181-1193   [Pub Med ID: 27841751]   [Pub Med Central ID: PMC5108346] [DOI:10.1107/S2059798316014716]


Here's how your body transports zinc to protect your health

--References publication:  Circulatory zinc transport is controlled by distinct interdomain sites on mammalian albumins..  Handing KB, Shabalin IG, Kassaar O, Khazaipoul S, Blindauer CA, Stewart AJ, Chruszcz M, Minor W.  Chem Sci   7:6635-6648   [Pub Med ID: 28567254]   [Pub Med Central ID: PMC5450522] [DOI:10.1039/c6sc02267g]

--References structures:  5IJE , 5IIU , 5IIX , 5IJ5 , 5IJF , 5IIH , 5HOZ

A Heart-Shaped Protein

Big DATA en Biomedicina. Wladek Minor: el cerebro estratégico

NPR Interview with Wladek Minor

by Sandy Hausman. Dec 21, 2015

Is the Precision Medicine Initiative really necessary?

HKL3000 Workshop in Shanghai

Rescuing vast amounts of scientific knowledge

About ProteinDiffraction.org: The Integrated Resource for Reproducibility in Macromolecular Crystallography

Fertilization Discovery: Do Sperm Carry Tiny Harpoons?

--References publication:  Sperm Lysozyme-Like Protein 1 (SLLP1), an intra-acrosomal oolemmal-binding sperm protein, reveals filamentous organization in protein crystal form..  Zheng H, Mandal A, Shumilin IA, Chordia MD, Panneerdoss S, Herr JC, Minor W.  Andrology   3:756-71   [Pub Med ID: 26198801]   [Pub Med Central ID: PMC5040164] [DOI:10.1111/andr.12057]

--References structures:  4YF2

HKL Suite Paper 23rd most cited scientific paper

The paper describing the HKL suite is #23 on the list of the 100 most cited scientific papers of all-time (#7 among papers published in the last 20 years). Published in Nature, Vol 514:550-3. October

--References publication:  Processing of X-ray diffraction data collected in oscillation mode..  Otwinowski Z, Minor W.  Methods Enzymol   276:307-26   [Pub Med ID: 27754618] [DOI:10.1016/S0076-6879(97)76066-X]


Protein Science Video Highlight of "Double Trouble"

--References publication:  Double trouble-Buffer selection and His-tag presence may be responsible for nonreproducibility of biomedical experiments..  Majorek KA, Kuhn ML, Chruszcz M, Anderson WF, Minor W.  Protein Sci   23:1359-68   [Pub Med ID: 25044180]   [Pub Med Central ID: PMC4286991] [DOI:10.1002/pro.2520]


NIAID Structure of the Month

--References publication:  Structural, functional, and inhibition studies of a Gcn5-related N-acetyltransferase (GNAT) superfamily protein PA4794: a new C-terminal lysine protein acetyltransferase from pseudomonas aeruginosa..  Majorek KA, Kuhn ML, Chruszcz M, Anderson WF, Minor W.  J. Biol. Chem.   288:30223-35   [Pub Med ID: 24003232]   [Pub Med Central ID: PMC3798489] [DOI:10.1074/jbc.M113.501353]

--References structures:  5VDB , 5VD6 , 3PGP , 3KKW

Argonne National Lab Feature Story

--References publication:  Structural, functional, and inhibition studies of a Gcn5-related N-acetyltransferase (GNAT) superfamily protein PA4794: a new C-terminal lysine protein acetyltransferase from pseudomonas aeruginosa..  Majorek KA, Kuhn ML, Chruszcz M, Anderson WF, Minor W.  J. Biol. Chem.   288:30223-35   [Pub Med ID: 24003232]   [Pub Med Central ID: PMC3798489] [DOI:10.1074/jbc.M113.501353]

--References structures:  6EDD , 5VDB , 5VD6 , 5JPH , 5JQ4 , 4OAD , 4OAE , 4M3S , 4L8A , 4L89 , 4KOR , 4KOY , 4KOV , 4KOT , 4KOW , 4KUB , 4KUA , 4KOX , 4KOS , 4KOU , 4KLV , 4KLW , 4JXR , 4JXQ

Lab Highlight in Crystallography Times

October 2013
  • Wladek Minor Lab.   

Identifying Protein Functions

--References publication:  Identification of unknown protein function using metabolite cocktail screening..  Shumilin IA, Cymborowski M, Chertihin O, Jha KN, Herr JC, Lesley SA, Joachimiak A, Minor W.  Structure   20:1715-25   [Pub Med ID: 22940582]   [Pub Med Central ID: PMC3472112] [DOI:10.1016/j.str.2012.07.016]


Highlighted in FEBS Journal

--References publication:  Protein crystallography for non-crystallographers, or how to get the best (but not more) from published macromolecular structures..  Wlodawer A, Minor W, Dauter Z, Jaskolski M.  FEBS J   275:1-21   [Pub Med ID: 18034855]   [Pub Med Central ID: PMC4465431] [DOI:10.1111/j.1742-4658.2007.06178.x]


Czarny obraz polskiej nauki

(The Dark Side of Polish Science)

Peanut Allergy Breakthrough

--References publication:  Structural and immunologic characterization of Ara h 1, a major peanut allergen..  Chruszcz M, Maleki SJ, Majorek KA, Demas M, Bublin M, Solberg R, Hurlburt BK, Ruan S, Mattison CP, Mattisohn CP, Breiteneder H, Minor W.  J. Biol. Chem.   286:39318-27   [Pub Med ID: 21917921]   [Pub Med Central ID: PMC3234756] [DOI:10.1074/jbc.M111.270132]


Godfathers of Polish bioinformatics mafia

broadcast from Channel 1 - Polish Radio November 19, 2011

Wladek Minor made Honorary Professor at Liverpool

October 2009

U.Va. Researchers Determine the 3-D Structure of Anthrax Protein

--References structures:  3SLF , 3SLB , 3N0M , 3N0S , 3KZL , 3IJW , 3E4F

Crystallography Times Highlight

MCSG reaches 1000 protein structures

July 17, 2009

Inventor of the Year Award

Interview on Polish radio

Rzeczpospolita.pl article

The Success of Polish Scientists working in the USA

Argonne Researchers Contribute 1000th Structure to Protein Data Bank

Everybody knows Wladek

Liquid Handling for Crystallography

#2 most cited paper in the past decade