Structural Biology
We strive to understand biological systems using a combination of X-ray crystallography and other biophysical techniques. We are currently members of the Center for Structural Genomics of Infectious Disease, an NIAID project focused on human pathogens. We also focus on metal binding to proteins and the structural variability observed within crystal structures.
Methodology Development
We strive to increase scientific reproducibility by developing methods and algorithms that help ensure structural models accurately reflect the macromolecules of interest. Our tools are used in throughout the world and address a wide range of scientific problems, from diffraction image processing to metal environment geometries to data archiving.
Our worldwide collaborations have been exceptionally fruitful, resulting in joint publications with researchers from 79 different institutions from around the world. An interactive map shows the geographical distribution of these institutions. Additionally, we collaborate with many synchrotron beamlines, in particular, with the Structural Biology Center at the Advanced Photon Source.

Web Resources Developed in the Minor Lab

Check My Metal
A web server for the validation of metal binding sites in macromolecules.
Classification of Mg2+ binding sites in RNA crystal structures.
Automatic modeling of side-chain conformations
Diffraction Experiment Archive - (AKA The Integrated Resource for Reproducibility in Macromolecular Crystallography).
Protein purification and crystallization artifacts
PDB codes that can be used to detect crystallization artifacts using molecular replacement.
Platform for sharing electron density maps and their interpretations.
We provide data management services for the Center for Structural Genomics of Infectious Diseases.