• e-mail: matt@iwonka.med.virginia.edu
  • Co-author of 28 publications with the Minor Lab  (cited 925 times) [show]
  • Co-author of 60 structures with the Minor Lab [show]
  • Relative Citation Ratio (RCR): 34.47

  • Training Period: 2003-07, PhD <br/> 2007-11, Postdoc <br/> 2011-15, Instructor
  • Prior Institution: Juniata College, PA
  • Prior Degree: BSc, PhD (1998)
  • Project Title: The Xtaldb crystallization expert system and its application to the structure of the 5'-nucleotidase YfbR
  • Current Position: CCRi (Commonwealth Computer Research, Inc), Charlottesville, VA

Publications with the Minor Lab

  1. Majorek KA, Zimmerman MD, Grabowski M, Shabalin I, Zheng H, Minor W (2020)
    Assessment of Crystallographic Structure Quality and Protein–Ligand Complex Structure Validation
    in Structural Biology in Drug Discovery: Methods, Techniques, and Practices : 253-275. [DOI:10.1002/9781118681121.ch11]
  2. Grabowski M, Langner KM, Cymborowski M, Porebski PJ, Sroka P, Zheng H, Cooper DR, Zimmerman MD, Elsliger MA, Burley SK, Minor W (2016)
    A public database of macromolecular diffraction experiments.
    Acta Crystallogr D Struct Biol 72: 1181-1193. [DOI:10.1107/S2059798316014716] [Pub Med ID: 27841751] [Pub Med Central ID: PMC5108346] Times cited: 40
  3. Grabowski M, Niedzialkowska E, Zimmerman MD, Minor W (2016)
    The impact of structural genomics: the first quindecennial.
    J. Struct. Funct. Genomics 17: 1-16. [DOI:10.1007/s10969-016-9201-5] [Pub Med ID: 26935210] [Pub Med Central ID: PMC4834271] Times cited: 23
    F1000 Recommended Publication
  4. Hou J, Zheng H, Chruszcz M, Zimmerman MD, Shumilin IA, Osinski T, Demas M, Grimshaw S, Minor W (2015)
    Dissecting the Structural Elements for the Activation of β-Ketoacyl-(Acyl Carrier Protein) Reductase from Vibrio cholerae.
    J. Bacteriol. 198: 463-76. [DOI:10.1128/JB.00360-15] [Pub Med ID: 26553852] [Pub Med Central ID: PMC4719456] Times cited: 6
  5. Berman HM, Gabanyi MJ, Groom CR, Johnson JE, Murshudov GN, Nicholls RA, Reddy V, Schwede T, Zimmerman MD, Westbrook J, Minor W (2015)
    Data to knowledge: how to get meaning from your result.
    IUCrJ 2: 45-58. [DOI:10.1107/S2052252514023306] [Pub Med ID: 25610627] [Pub Med Central ID: PMC4285880] Times cited: 8
  6. Zheng H, Handing KB, Zimmerman MD, Shabalin IG, Almo SC, Minor W (2015)
    X-ray crystallography over the past decade for novel drug discovery - where are we heading next?
    Expert Opin Drug Discov 10: 975-89. [DOI:10.1517/17460441.2015.1061991] [Pub Med ID: 26177814] [Pub Med Central ID: PMC4655606] Times cited: 28
  7. Zheng H, Hou J, Zimmerman MD, Wlodawer A, Minor W (2014)
    The future of crystallography in drug discovery.
    Expert Opin Drug Discov 9: 125-37. [DOI:10.1517/17460441.2014.872623] [Pub Med ID: 24372145] [Pub Med Central ID: PMC4106240] Times cited: 28
  8. Domagalski MJ, Zheng H, Zimmerman MD, Dauter Z, Wlodawer A, Minor W (2014)
    The quality and validation of structures from structural genomics.
    Methods Mol. Biol. 1091: 297-314. [DOI:10.1007/978-1-62703-691-7_21] [Pub Med ID: 24203341] [Pub Med Central ID: PMC4081469] Times cited: 11
  9. Zimmerman MD, Grabowski M, Domagalski MJ, Maclean EM, Chruszcz M, Minor W (2014)
    Data management in the modern structural biology and biomedical research environment.
    Methods Mol. Biol. 1140: 1-25. [DOI:10.1007/978-1-4939-0354-2_1] [Pub Med ID: 24590705] [Pub Med Central ID: PMC4086192] Times cited: 18
  10. Gront D, Grabowski M, Zimmerman MD, Raynor J, Tkaczuk KL, Minor W (2012)
    Assessing the accuracy of template-based structure prediction metaservers by comparison with structural genomics structures.
    J. Struct. Funct. Genomics 13: 213-25. [DOI:10.1007/s10969-012-9146-2] [Pub Med ID: 23086054] [Pub Med Central ID: PMC4105012] Times cited: 6
  11. Majorek KA, Porebski PJ, Dayal A, Zimmerman MD, Jablonska K, Stewart AJ, Chruszcz M, Minor W (2012)
    Structural and immunologic characterization of bovine, horse, and rabbit serum albumins.
    Mol. Immunol. 52: 174-82. [DOI:10.1016/j.molimm.2012.05.011] [Pub Med ID: 22677715] [Pub Med Central ID: PMC3401331] Times cited: 370
  12. Klimecka MM, Chruszcz M, Font J, Skarina T, Shumilin I, Onopryienko O, Porebski PJ, Cymborowski M, Zimmerman MD, Hasseman J, Glomski IJ, Lebioda L, Savchenko A, Edwards A, Minor W (2011)
    Structural analysis of a putative aminoglycoside N-acetyltransferase from Bacillus anthracis.
    J. Mol. Biol. 410: 411-23. [DOI:10.1016/j.jmb.2011.04.076] [Pub Med ID: 21601576] [Pub Med Central ID: PMC3131501] Times cited: 9
  13. Gabanyi MJ, Adams PD, Arnold K, Bordoli L, Carter LG, Flippen-Andersen J, Gifford L, Haas J, Kouranov A, McLaughlin WA, Micallef DI, Minor W, Shah R, Schwede T, Tao YP, Westbrook JD, Zimmerman M, Berman HM (2011)
    The Structural Biology Knowledgebase: a portal to protein structures, sequences, functions, and methods.
    J. Struct. Funct. Genomics 12: 45-54. [DOI:10.1007/s10969-011-9106-2] [Pub Med ID: 21472436] [Pub Med Central ID: PMC3123456] Times cited: 42
  14. Cymborowski M, Klimecka M, Chruszcz M, Zimmerman MD, Shumilin IA, Borek D, Lazarski K, Joachimiak A, Otwinowski Z, Anderson W, Minor W (2010)
    To automate or not to automate: this is the question.
    J. Struct. Funct. Genomics 11: 211-21. [DOI:10.1007/s10969-010-9092-9] [Pub Med ID: 20526815] [Pub Med Central ID: PMC2921494] Times cited: 19
  15. Sledź P, Kamiński R, Chruszcz M, Zimmerman MD, Minor W, Woźniak K (2010)
    An experimental charge density of HEPES.
    Acta Crystallogr., B 66: 482-92. [DOI:10.1107/S0108768110023025] [Pub Med ID: 20631430] Times cited: 11
  16. Sledz P, Zheng H, Murzyn K, Chruszcz M, Zimmerman MD, Chordia MD, Joachimiak A, Minor W (2010)
    New surface contacts formed upon reductive lysine methylation: improving the probability of protein crystallization.
    Protein Sci. 19: 1395-404. [DOI:10.1002/pro.420] [Pub Med ID: 20506323] [Pub Med Central ID: PMC2974831] Times cited: 24
  17. Luo HB, Zheng H, Zimmerman MD, Chruszcz M, Skarina T, Egorova O, Savchenko A, Edwards AM, Minor W (2010)
    Crystal structure and molecular modeling study of N-carbamoylsarcosine amidase Ta0454 from Thermoplasma acidophilum.
    J. Struct. Biol. 169: 304-11. [DOI:10.1016/j.jsb.2009.11.008] [Pub Med ID: 19932181] [Pub Med Central ID: PMC2830209] Times cited: 13
  18. Koclega KD, Chruszcz M, Zimmerman MD, Bujacz G, Minor W (2009)
    'Hot' macromolecular crystals.
    Cryst Growth Des 10: 580. [DOI:10.1021/cg900971h] [Pub Med ID: 20161694] [Pub Med Central ID: PMC2809425] Times cited: 5
  19. Grabowski M, Chruszcz M, Zimmerman MD, Kirillova O, Minor W (2009)
    Benefits of structural genomics for drug discovery research.
    Infect Disord Drug Targets 9: 459-74. [Pub Med ID: 19594422] [Pub Med Central ID: PMC2866842] Times cited: 26
  20. Wang S, Kirillova O, Chruszcz M, Gront D, Zimmerman MD, Cymborowski MT, Shumilin IA, Skarina T, Gorodichtchenskaia E, Savchenko A, Edwards AM, Minor W (2009)
    The crystal structure of the AF2331 protein from Archaeoglobus fulgidus DSM 4304 forms an unusual interdigitated dimer with a new type of alpha + beta fold.
    Protein Sci. 18: 2410-9. [DOI:10.1002/pro.251] [Pub Med ID: 19768810] [Pub Med Central ID: PMC2788295] Times cited: 2
  21. Chruszcz M, Zimmerman MD, Wang S, Koclega KD, Zheng H, Evdokimova E, Kudritska M, Cymborowski M, Savchenko A, Edwards A, Minor W (2008)
    Function-biased choice of additives for optimization of protein crystallization - the case of the putative thioesterase PA5185 from Pseudomonas aeruginosa PAO1.
    Cryst Growth Des 8: 4054-4061. [DOI:10.1021/cg800430f] [Pub Med ID: 19898606] [Pub Med Central ID: PMC2700756] Times cited: 3
  22. Beloglazova N, Brown G, Zimmerman MD, Proudfoot M, Makarova KS, Kudritska M, Kochinyan S, Wang S, Chruszcz M, Minor W, Koonin EV, Edwards AM, Savchenko A, Yakunin AF (2008)
    A novel family of sequence-specific endoribonucleases associated with the clustered regularly interspaced short palindromic repeats.
    J. Biol. Chem. 283: 20361-71. [DOI:10.1074/jbc.M803225200] [Pub Med ID: 18482976] [Pub Med Central ID: PMC2459268] Times cited: 127
  23. Zimmerman MD, Proudfoot M, Yakunin A, Minor W (2008)
    Structural insight into the mechanism of substrate specificity and catalytic activity of an HD-domain phosphohydrolase: the 5'-deoxyribonucleotidase YfbR from Escherichia coli.
    J. Mol. Biol. 378: 215-26. [DOI:10.1016/j.jmb.2008.02.036] [Pub Med ID: 18353368] [Pub Med Central ID: PMC2504004] Times cited: 48
  24. Chruszcz M, Potrzebowski W, Zimmerman MD, Grabowski M, Zheng H, Lasota P, Minor W (2008)
    Analysis of solvent content and oligomeric states in protein crystals--does symmetry matter?
    Protein Sci. 17: 623-32. [DOI:10.1110/ps.073360508] [Pub Med ID: 18359856] [Pub Med Central ID: PMC2271157] Times cited: 34
  25. Koclega KD, Chruszcz M, Zimmerman MD, Cymborowski M, Evdokimova E, Minor W (2007)
    Crystal structure of a transcriptional regulator TM1030 from Thermotoga maritima solved by an unusual MAD experiment.
    J. Struct. Biol. 159: 424-32. [DOI:10.1016/j.jsb.2007.04.012] [Pub Med ID: 17588774] [Pub Med Central ID: PMC2093942] Times cited: 8
  26. Petkowski JJ, Chruszcz M, Zimmerman MD, Zheng H, Skarina T, Onopriyenko O, Cymborowski MT, Koclega KD, Savchenko A, Edwards A, Minor W (2007)
    Crystal structures of TM0549 and NE1324--two orthologs of E. coli AHAS isozyme III small regulatory subunit.
    Protein Sci. 16: 1360-7. [DOI:10.1110/ps.072793807] [Pub Med ID: 17586771] [Pub Med Central ID: PMC2206681] Times cited: 15
  27. Doyle CR, Zimmerman MD, Chruszcz M, Cymborowski M, Gawlicka-Chruszcz A, Minor W (2006)
    Crystal structure of 6-(4-difluoromethoxy-3-methoxyphenyl)-3(2H)-pyridazinone,C12H10F2N2O3.
    Zeitschrift fur Kristallographie 221: 359-360. [DOI:10.1524/ncrs.2006.0109]
  28. Zimmerman MD, Chruszcz M, Cymborowski M, Zheng HP, Minor W (2006)
    Disodium 4-nitrophenylphosphate hexahydrate.
    Acta Crystallogr Sect E Struct Rep Online 62: M884-M886. [DOI:10.1107/S160053680600941X] Times cited: 1