• Training Period: 2010-18
  • Prior Institution: Sichuan University, China; Sun Yat-Sen University,China
  • Prior Degree: PhD (2006)
  • Project Title: Structural and functional studies of fatty acid synthesis enzymes from pathogenic bacteria
  • Current Position: Martha Jefferson Hospital, Charlottesville, USA

Education:
  • B.S. (Biology), Sichuan University, Chengdu, China (1994)
  • M.S. (Biochemistry), West China University of Medical Sciences, Chengdu, China (1997)
  • Ph.D. (Pharmacology), Sun Yat-Sen University, Guangzhou, China (2006)
Research Interest:
  • Structural and functional studies of proteins essential for the survival of pathogens using combinations of X-ray crystallography and other biological/biophysical methods
Projects:
  • vcFabH1, vcFabH2, vcFabB and vcFabF which catalyze the condensation reaction in the elongation cycle of fatty acid synthesis in V. cholerae.
  • FabGs from V. cholerae, B. anthracis, L. monocytogenes, H. pylori
  • cyclohexadienyl dehydrogenase from S. meliloti and B. anthracis
  • A putative diacylglycerol kinase from B. anthracis
  • A putative metal-binding protein from B. anthracis

Publications with the Minor Lab

  1. Shabalin IG, Gritsunov A, Hou J, Sławek J, Miks CD, Cooper DR, Minor W, Christendat D (2019)
    Structural and biochemical analysis of Bacillus anthracis prephenate dehydrogenase reveals an unusual mode of inhibition by tyrosine via the ACT domain.
    FEBS J. 287: 2235-2255. [DOI:10.1111/febs.15150] [Pub Med ID: 31750992] [Pub Med Central ID: PMC7239764]
  2. Hou J, Zheng H, Tzou WS, Cooper DR, Chruszcz M, Chordia MD, Kwon K, Grabowski M, Minor W (2018)
    Differences in substrate specificity of V. cholerae FabH enzymes suggest new approaches for the development of novel antibiotics and biofuels.
    FEBS J. 285: 2900-2921. [DOI:10.1111/febs.14588] [Pub Med ID: 29917313] [Pub Med Central ID: PMC6105497] Times cited: 1
  3. Zheng H, Langner KM, Shields GP, Hou J, Kowiel M, Allen FH, Murshudov G, Minor W (2017)
    Data mining of iron(II) and iron(III) bond-valence parameters, and their relevance for macromolecular crystallography.
    Acta Crystallogr D Struct Biol 73: 316-325. [DOI:10.1107/S2059798317000584] [Pub Med ID: 28375143] [Pub Med Central ID: PMC5503122] Times cited: 8
  4. Hou J, Zheng H, Chruszcz M, Zimmerman MD, Shumilin IA, Osinski T, Demas M, Grimshaw S, Minor W (2015)
    Dissecting the Structural Elements for the Activation of β-Ketoacyl-(Acyl Carrier Protein) Reductase from Vibrio cholerae.
    J. Bacteriol. 198: 463-76. [DOI:10.1128/JB.00360-15] [Pub Med ID: 26553852] [Pub Med Central ID: PMC4719456] Times cited: 7
  5. Zheng H, Hou J, Zimmerman MD, Wlodawer A, Minor W (2014)
    The future of crystallography in drug discovery.
    Expert Opin Drug Discov 9: 125-37. [DOI:10.1517/17460441.2014.872623] [Pub Med ID: 24372145] [Pub Med Central ID: PMC4106240] Times cited: 34
  6. Hou J, Wojciechowska K, Zheng H, Chruszcz M, Cooper DR, Cymborowski M, Skarina T, Gordon E, Luo H, Savchenko A, Minor W (2012)
    Structure of a short-chain dehydrogenase/reductase from Bacillus anthracis.
    Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 68: 632-7. [DOI:10.1107/S1744309112017939] [Pub Med ID: 22684058] [Pub Med Central ID: PMC3370898] Times cited: 2