Co-author of 2 structures with the Minor Lab
James Madison High School, Vienna, VA -- Class of 2015
B.Sc. in Chemistry with Specialization in Biochemistry, University of Virginia -- expected graduation in 2019
Dihydroorotase as a potential drug target to inhibit pyrimidine biosynthesis in pathogens
Tyrosine biosynthesis in bacteria and mechanisms of prephenate dehydrogenase inhibition
Actin-binding protein involved with neuronal morphogenesis in humans
Protein structure determination and refinement
One of my projects includes the protein, dihydroorotase (DHO), which is necessary for de novo pyrimidine biosynthesis. Because this pathway is essential for pathogenic proliferation, DHO serves as an attractive drug target for the development of novel antimicrobial agents through inhibition. My goal is to contribute to the inventory of and classify all known DHO structures, as well as characterize all bound DHO ligands reported in the context of DrugBank. Examination of the similarities and differences between DHO from various species is thought to be an essential step in fighting the rise of antimicrobial resistance.
Another project of mine focuses on obtaining structural data for proteins with unknown functions studied by the Center for Structural Genomics of Infectious Diseases (CSGID). This requires optimizing crystallization conditions to generate previously unknown protein models. The overarching goal is to provide a novel understanding of how allosteric regulators, cofactors, and substrates affect protein conformation and function in different pathogenic organisms to assist in drug discovery and disease prevention.
Member of Phi Beta Kappa (2018)
Recipient of Intermediate Honors at the University of Virginia (2017)
Recipient of the George Washington University School of Engineering and Applied Science Award (2014)