Ivan Shabalin

Research Scientist


Education:
  • M.Sc. - Moscow State University (2006)
  • Ph.D. in Chemistry - A.N. Bach Institute of Biochemistry, Russian Academy of Sciences (2010)
Research Interest:
  • High-throughput structure determination and functional studies of proteins from pathogens causing emerging and re-emerging infectious diseases using combination of X-ray crystallography and other biophysical/biological methods.
  • Developing of integrative techniques for highly efficient protein crystallization with a goal of maximizing the number of successful crystallizations, yet minimizing the resources used.
  • Macromolecular structure elucidation and refinement. Exploration of novel methods for crystallographic structure solution and solving "mission impossible" structures.
  • Various aspects of quality assessment of crystallographic protein structures.
  • Metal binding to RNA and protein. Developing of a protocol for Mg-binding sites validation and classification in RNA crystal structures.
CV:

15 peer reviewed publications.
More than 80 protein structures in the PDB.
Recipient of the Best Postdoc Poster Award at 43rd Mid-Atlantic Macromolecular Crystallography Meeting (2013).
Four awards during graduate/undergraduate studies.


Publications with the Minor Lab

  1. Niedzialkowska E, Gasiorowska O, Handing KB, Majorek KA, Porebski PJ, Shabalin IG, Zasadzinska E, Cymborowski M, Minor W (2016)
    Protein purification and crystallization artifacts: The tale usually not told.
    Protein science : a publication of the Protein Society 25: 720-33 Times cited: 3 [Pub Med ID: 26660914] [Pub Med Central ID: PMC4815408]
  2. Handing KB, Shabalin IG, Szlachta K, Majorek KA, Minor W (2016)
    Crystal structure of equine serum albumin in complex with cetirizine reveals a novel drug binding site.
    Molecular immunology 71: 143-51 Times cited: 2 [Pub Med ID: 26896718] [Pub Med Central ID: PMC4800003]
  3. Shabalin I, Dauter Z, Jaskolski M, Minor W, Wlodawer A (2015)
    Crystallography and chemistry should always go together: a cautionary tale of protein complexes with cisplatin and carboplatin.
    Acta crystallographica. Section D, Structural biology 71: 1965-79 Times cited: 14 [Pub Med ID: 26327386] [Pub Med Central ID: PMC4556316]
  4. Zheng H, Shabalin IG, Handing KB, Bujnicki JM, Minor W (2015)
    Magnesium-binding architectures in RNA crystal structures: validation, binding preferences, classification and motif detection.
    Nucleic acids research 43: 3789-801 Times cited: 3 [Pub Med ID: 25800744] [Pub Med Central ID: PMC4402538]
  5. Zheng H, Handing KB, Zimmerman MD, Shabalin IG, Almo SC, Minor W (2015)
    X-ray crystallography over the past decade for novel drug discovery - where are we heading next?
    Expert opinion on drug discovery 10: 975-89 Times cited: 4 [Pub Med ID: 26177814] [Pub Med Central ID: PMC4655606]
  6. Shabalin IG, Porebski PJ, Cooper DR, Grabowski M, Onopriyenko O, Grimshaw S, Savchenko A, Chruszcz M, Minor W (2012)
    Structure of anabolic ornithine carbamoyltransferase from Campylobacter jejuni at 2.7 Å resolution.
    Acta crystallographica. Section F, Structural biology and crystallization communications 68: 1018-24 Times cited: 3 [Pub Med ID: 22949186] [Pub Med Central ID: PMC3433189]

Structures with the Minor Lab Go to top