Heping Zheng

Research Scientist


Education:
  • B.Sc. (Biological Science) University of Science and Technology of China (2001)
  • B.E. (Computer Science) University of Science and Technology of China (2001)
  • Ph.D. (Structural biology, Computational biology and Biological Physics) University of Virginia (2009)

Publications with the Minor Lab

  1. Zheng H, Langner KM, Shields GP, Hou J, Kowiel M, Allen FH, Murshudov G, Minor W (2017)
    Data mining of iron(II) and iron(III) bond-valence parameters, and their relevance for macromolecular crystallography.
    Acta Crystallogr D Struct Biol 73: 316-325 [Pub Med ID: 28375143]
  2. Zheng H, Cooper DR, Porebski PJ, Shabalin IG, Handing KB, Minor W (2017)
    CheckMyMetal: a macromolecular metal-binding validation tool.
    Acta Crystallogr D Struct Biol 73: 223-233 [Pub Med ID: 28291757] [Pub Med Central ID: PMC534943]
  3. Grabowski M, Langner KM, Cymborowski M, Porebski PJ, Sroka P, Zheng H, Cooper DR, Zimmerman MD, Elsliger MA, Burley SK, Minor W (2016)
    A public database of macromolecular diffraction experiments.
    Acta Crystallogr D Struct Biol 72: 1181-1193 Times cited: 3 [Pub Med ID: 27841751] [Pub Med Central ID: PMC5108346]
  4. Hou J, Zheng H, Chruszcz M, Zimmerman MD, Shumilin IA, Osinski T, Demas M, Grimshaw S, Minor W (2015)
    Dissecting the Structural Elements for the Activation of β-Ketoacyl-(Acyl Carrier Protein) Reductase from Vibrio cholerae.
    J. Bacteriol. 198: 463-76 Times cited: 1 [Pub Med ID: 26553852] [Pub Med Central ID: PMC4719456]
  5. Zheng H, Mandal A, Shumilin IA, Chordia MD, Panneerdoss S, Herr JC, Minor W (2015)
    Sperm Lysozyme-Like Protein 1 (SLLP1), an intra-acrosomal oolemmal-binding sperm protein, reveals filamentous organization in protein crystal form.
    Andrology 3: 756-71 Times cited: 2 [Pub Med ID: 26198801] [Pub Med Central ID: PMC5040164]
  6. Zheng H, Shabalin IG, Handing KB, Bujnicki JM, Minor W (2015)
    Magnesium-binding architectures in RNA crystal structures: validation, binding preferences, classification and motif detection.
    Nucleic Acids Res. 43: 3789-801 Times cited: 9 [Pub Med ID: 25800744] [Pub Med Central ID: PMC4402538]
  7. Zheng H, Handing KB, Zimmerman MD, Shabalin IG, Almo SC, Minor W (2015)
    X-ray crystallography over the past decade for novel drug discovery - where are we heading next?
    Expert Opin Drug Discov 10: 975-89 Times cited: 6 [Pub Med ID: 26177814] [Pub Med Central ID: PMC4655606]
  8. Zheng H, Hou J, Zimmerman MD, Wlodawer A, Minor W (2014)
    The future of crystallography in drug discovery.
    Expert Opin Drug Discov 9: 125-37 Times cited: 10 [Pub Med ID: 24372145] [Pub Med Central ID: PMC4106240]
  9. Domagalski MJ, Zheng H, Zimmerman MD, Dauter Z, Wlodawer A, Minor W (2014)
    The quality and validation of structures from structural genomics.
    Methods Mol. Biol. 1091: 297-314 Times cited: 6 [Pub Med ID: 24203341] [Pub Med Central ID: PMC4081469]
  10. Zheng H, Chordia MD, Cooper DR, Chruszcz M, Müller P, Sheldrick GM, Minor W (2014)
    Validation of metal-binding sites in macromolecular structures with the CheckMyMetal web server.
    Nat Protoc 9: 156-70 Times cited: 81 [Pub Med ID: 24356774] [Pub Med Central ID: PMC4410975]
  11. Luo HB, Knapik AA, Petkowski JJ, Demas M, Shumilin IA, Zheng H, Chruszcz M, Minor W (2013)
    Biophysical analysis of the putative acetyltransferase SACOL2570 from methicillin-resistant Staphylococcus aureus.
    J. Struct. Funct. Genomics 14: 97-108 [Pub Med ID: 23963951] [Pub Med Central ID: PMC3923901]
  12. Hou J, Wojciechowska K, Zheng H, Chruszcz M, Cooper DR, Cymborowski M, Skarina T, Gordon E, Luo H, Savchenko A, Minor W (2012)
    Structure of a short-chain dehydrogenase/reductase from Bacillus anthracis.
    Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 68: 632-7 Times cited: 1 [Pub Med ID: 22684058] [Pub Med Central ID: PMC3370898]
  13. Zheng H, Filippova EV, Tkaczuk KL, Dworzynski P, Chruszcz M, Porebski PJ, Wawrzak Z, Onopriyenko O, Kudritska M, Grimshaw S, Savchenko A, Anderson WF, Minor W (2012)
    Crystal structures of putative phosphoglycerate kinases from B. anthracis and C. jejuni.
    J. Struct. Funct. Genomics 13: 15-26 Times cited: 1 [Pub Med ID: 22403005] [Pub Med Central ID: PMC4485498]
  14. Sledz P, Zheng H, Murzyn K, Chruszcz M, Zimmerman MD, Chordia MD, Joachimiak A, Minor W (2010)
    New surface contacts formed upon reductive lysine methylation: improving the probability of protein crystallization.
    Protein Sci. 19: 1395-404 Times cited: 22 [Pub Med ID: 20506323] [Pub Med Central ID: PMC2974831]
  15. Luo HB, Zheng H, Zimmerman MD, Chruszcz M, Skarina T, Egorova O, Savchenko A, Edwards AM, Minor W (2010)
    Crystal structure and molecular modeling study of N-carbamoylsarcosine amidase Ta0454 from Thermoplasma acidophilum.
    J. Struct. Biol. 169: 304-11 Times cited: 11 [Pub Med ID: 19932181] [Pub Med Central ID: PMC2830209]
  16. Chruszcz M, Zimmerman MD, Wang S, Koclega KD, Zheng H, Evdokimova E, Kudritska M, Cymborowski M, Savchenko A, Edwards A, Minor W (2008)
    Function-biased choice of additives for optimization of protein crystallization - the case of the putative thioesterase PA5185 from Pseudomonas aeruginosa PAO1.
    Cryst Growth Des 8: 4054-4061 Times cited: 2 [Pub Med ID: 19898606] [Pub Med Central ID: PMC2700756]
  17. Zheng H, Chruszcz M, Lasota P, Lebioda L, Minor W (2008)
    Data mining of metal ion environments present in protein structures.
    J. Inorg. Biochem. 102: 1765-76 Times cited: 118 [Pub Med ID: 18614239] [Pub Med Central ID: PMC2872550]
  18. Jha KN, Shumilin IA, Digilio LC, Chertihin O, Zheng H, Schmitz G, Visconti PE, Flickinger CJ, Minor W, Herr JC (2008)
    Biochemical and structural characterization of apolipoprotein A-I binding protein, a novel phosphoprotein with a potential role in sperm capacitation.
    Endocrinology 149: 2108-20 Times cited: 26 [Pub Med ID: 18202122] [Pub Med Central ID: PMC2329272]
  19. Chruszcz M, Potrzebowski W, Zimmerman MD, Grabowski M, Zheng H, Lasota P, Minor W (2008)
    Analysis of solvent content and oligomeric states in protein crystals--does symmetry matter?
    Protein Sci. 17: 623-32 Times cited: 23 [Pub Med ID: 18359856] [Pub Med Central ID: PMC2271157]
  20. Zheng H, Gawlicka-Chruszcz A, Cymborowski M, Minor W (2007)
    trans-1-Hydroxycyclopentan-2-aminium chloride.
    Acta Crystallogr Sect E Struct Rep Online 63: O2697-O2698
  21. Dong A, Xu X, Edwards AM, , , Chang C, Chruszcz M, Cuff M, Cymborowski M, Di Leo R, Egorova O, Evdokimova E, Filippova E, Gu J, Guthrie J, Ignatchenko A, Joachimiak A, Klostermann N, Kim Y, Korniyenko Y, Minor W, Que Q, Savchenko A, Skarina T, Tan K, Yakunin A, Yee A, Yim V, Zhang R, Zheng H, Akutsu M, Arrowsmith C, Avvakumov GV, Bochkarev A, Dahlgren LG, Dhe-Paganon S, Dimov S, Dombrovski L, Finerty P, Flodin S, Flores A, Gräslund S, Hammerström M, Herman MD, Hong BS, Hui R, Johansson I, Liu Y, Nilsson M, Nedyalkova L, Nordlund P, Nyman T, Min J, Ouyang H, Park HW, Qi C, Rabeh W, Shen L, Shen Y, Sukumard D, Tempel W, Tong Y, Tresagues L, Vedadi M, Walker JR, Weigelt J, Welin M, Wu H, Xiao T, Zeng H, Zhu H (2007)
    In situ proteolysis for protein crystallization and structure determination.
    Nat. Methods 4: 1019-21 Times cited: 131 [Pub Med ID: 17982461] [Pub Med Central ID: PMC3366506]
  22. Petkowski JJ, Chruszcz M, Zimmerman MD, Zheng H, Skarina T, Onopriyenko O, Cymborowski MT, Koclega KD, Savchenko A, Edwards A, Minor W (2007)
    Crystal structures of TM0549 and NE1324--two orthologs of E. coli AHAS isozyme III small regulatory subunit.
    Protein Sci. 16: 1360-7 Times cited: 12 [Pub Med ID: 17586771] [Pub Med Central ID: PMC2206681]
  23. Zuo Y, Zheng H, Wang Y, Chruszcz M, Cymborowski M, Skarina T, Savchenko A, Malhotra A, Minor W (2007)
    Crystal structure of RNase T, an exoribonuclease involved in tRNA maturation and end turnover.
    Structure 15: 417-28 Times cited: 27 [Pub Med ID: 17437714] [Pub Med Central ID: PMC1907377]
  24. Gawlicka-Chruszcz A, Zheng H, Hyacinth M, Cymborowski M, Sabat M, Minor W (2006)
    Crystal structure of 2,6-dichlorobenzaldehyde,C7H4Cl2O.
    Zeitschrift fur Kristallographie 221: 545-546 Times cited: 2
  25. Zimmerman MD, Chruszcz M, Cymborowski M, Zheng HP, Minor W (2006)
    Disodium 4-nitrophenylphosphate hexahydrate.
    Acta Crystallogr Sect E Struct Rep Online 62: M884-M886 Times cited: 1
  26. Chruszcz M, Zheng HP, Cymborowski M, Gawlicka-Chruszcz A, Minor W (2005)
    3-(Morpholinium-1-yl)propanesulfonate.
    Acta Crystallogr Sect E Struct Rep Online 61: O3190-O3191 Times cited: 4

Structures with the Minor Lab Go to top