Education:
  • PhD, biological sciences - biophysics, 2014, Jagiellonian University
    "Improvement of model building and refinement of macromolecular crystal structures”
    Research done at the University of Virginia in the Minor Lab.
  • MSc, biotechnology, 2009, Jagiellonian University
    "Structural and comparative analysis of dethiobiotin synthetase from Helicobacter pylori"
Research Interest:
  • Methods development for macromolecular crystallography
  • Validation of macromolecular structures
  • Structural bioinformatics
Projects:
  • Molstack
    platform for sharing density maps and their interpretations
  • Fitmunk
    automatic modeling of side-chain conformations
Google Scholar profile

Publications with the Minor Lab Go to top

  1. Kowiel M, Brzezinski D, Porebski PJ, Shabalin IG, Jaskolski M, Minor W (2018)
    Automatic Recognition of Ligands in Electron Density by Machine Learning.
    Bioinformatics : [Pub Med ID: 30016407]
  2. Wlodawer A, Dauter Z, Porebski PJ, Minor W, Stanfield R, Jaskolski M, Pozharski E, Weichenberger CX, Rupp B (2018)
    Detect, correct, retract: How to manage incorrect structural models.
    FEBS J. 285: 444-466 [Pub Med ID: 29113027] [Pub Med Central ID: PMC5799025]
  3. Porebski PJ, Sroka P, Zheng H, Cooper DR, Minor W (2018)
    Molstack-Interactive visualization tool for presentation, interpretation, and validation of macromolecules and electron density maps.
    Protein Sci. 27: 86-94 Times cited: 3 [Pub Med ID: 28815771] [Pub Med Central ID: PMC5734276]
  4. Zheng H, Cooper DR, Porebski PJ, Shabalin IG, Handing KB, Minor W (2017)
    CheckMyMetal: a macromolecular metal-binding validation tool.
    Acta Crystallogr D Struct Biol 73: 223-233 Times cited: 15 [Pub Med ID: 28291757] [Pub Med Central ID: PMC5349434]
  5. Zheng H, Porebski PJ, Grabowski M, Cooper DR, Minor W (2017)
    Databases, Repositories, and Other Data Resources in Structural Biology.
    Methods Mol. Biol. 1607: 643-665 [Pub Med ID: 28573593] [Pub Med Central ID: PMC5587190]
  6. Grabowski M, Langner KM, Cymborowski M, Porebski PJ, Sroka P, Zheng H, Cooper DR, Zimmerman MD, Elsliger MA, Burley SK, Minor W (2016)
    A public database of macromolecular diffraction experiments.
    Acta Crystallogr D Struct Biol 72: 1181-1193 Times cited: 17 [Pub Med ID: 27841751] [Pub Med Central ID: PMC5108346]
  7. Niedzialkowska E, Gasiorowska O, Handing KB, Majorek KA, Porebski PJ, Shabalin IG, Zasadzinska E, Cymborowski M, Minor W (2016)
    Protein purification and crystallization artifacts: The tale usually not told.
    Protein Sci. 25: 720-33 Times cited: 8 [Pub Med ID: 26660914] [Pub Med Central ID: PMC4815408]
  8. Porebski PJ, Cymborowski M, Pasenkiewicz-Gierula M, Minor W (2016)
    Fitmunk: improving protein structures by accurate, automatic modeling of side-chain conformations.
    Acta Crystallogr D Struct Biol 72: 266-80 Times cited: 8 [Pub Med ID: 26894674] [Pub Med Central ID: PMC4756610]
  9. Chruszcz M, Mikolajczak K, Mank N, Majorek KA, Porebski PJ, Minor W (2013)
    Serum albumins-unusual allergens.
    Biochim. Biophys. Acta 1830: 5375-81 Times cited: 36 [Pub Med ID: 23811341] [Pub Med Central ID: PMC4419372]
  10. Majorek KA, Porebski PJ, Dayal A, Zimmerman MD, Jablonska K, Stewart AJ, Chruszcz M, Minor W (2012)
    Structural and immunologic characterization of bovine, horse, and rabbit serum albumins.
    Mol. Immunol. 52: 174-82 Times cited: 230 [Pub Med ID: 22677715] [Pub Med Central ID: PMC3401331]
  11. Shabalin IG, Porebski PJ, Cooper DR, Grabowski M, Onopriyenko O, Grimshaw S, Savchenko A, Chruszcz M, Minor W (2012)
    Structure of anabolic ornithine carbamoyltransferase from Campylobacter jejuni at 2.7 Å resolution.
    Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 68: 1018-24 Times cited: 3 [Pub Med ID: 22949186] [Pub Med Central ID: PMC3433189]
  12. Chruszcz M, Chapman MD, Osinski T, Solberg R, Demas M, Porebski PJ, Majorek KA, Pomés A, Minor W (2012)
    Alternaria alternata allergen Alt a 1: a unique β-barrel protein dimer found exclusively in fungi.
    J. Allergy Clin. Immunol. 130: 241-7.e9 Times cited: 29 [Pub Med ID: 22664167] [Pub Med Central ID: PMC3391610]
  13. Niedzialkowska E, Wang F, Porebski PJ, Minor W, Higgins JM, Stukenberg PT (2012)
    Molecular basis for phosphospecific recognition of histone H3 tails by Survivin paralogues at inner centromeres.
    Mol. Biol. Cell 23: 1457-66 Times cited: 25 [Pub Med ID: 22357620] [Pub Med Central ID: PMC3327328]
  14. Chruszcz M, Pomés A, Glesner J, Vailes LD, Osinski T, Porebski PJ, Majorek KA, Heymann PW, Platts-Mills TA, Minor W, Chapman MD (2012)
    Molecular determinants for antibody binding on group 1 house dust mite allergens.
    J. Biol. Chem. 287: 7388-98 Times cited: 43 [Pub Med ID: 22210776] [Pub Med Central ID: PMC3293536]
  15. Zheng H, Filippova EV, Tkaczuk KL, Dworzynski P, Chruszcz M, Porebski PJ, Wawrzak Z, Onopriyenko O, Kudritska M, Grimshaw S, Savchenko A, Anderson WF, Minor W (2012)
    Crystal structures of putative phosphoglycerate kinases from B. anthracis and C. jejuni.
    J. Struct. Funct. Genomics 13: 15-26 Times cited: 3 [Pub Med ID: 22403005] [Pub Med Central ID: PMC4485498]
  16. Porebski PJ, Klimecka M, Chruszcz M, Nicholls RA, Murzyn K, Cuff ME, Xu X, Cymborowski M, Murshudov GN, Savchenko A, Edwards A, Minor W (2012)
    Structural characterization of Helicobacter pylori dethiobiotin synthetase reveals differences between family members.
    FEBS J. 279: 1093-105 Times cited: 6 [Pub Med ID: 22284390] [Pub Med Central ID: PMC3392494]
  17. Cooper DR, Porebski PJ, Chruszcz M, Minor W (2011)
    X-ray crystallography: Assessment and validation of protein-small molecule complexes for drug discovery.
    Expert Opin Drug Discov 6: 771-782 Times cited: 26 [Pub Med ID: 21779303] [Pub Med Central ID: PMC3138648]
  18. Klimecka MM, Chruszcz M, Font J, Skarina T, Shumilin I, Onopryienko O, Porebski PJ, Cymborowski M, Zimmerman MD, Hasseman J, Glomski IJ, Lebioda L, Savchenko A, Edwards A, Minor W (2011)
    Structural analysis of a putative aminoglycoside N-acetyltransferase from Bacillus anthracis.
    J. Mol. Biol. 410: 411-23 Times cited: 8 [Pub Med ID: 21601576] [Pub Med Central ID: PMC3131501]