• e-mail: matt@iwonka.med.virginia.edu
  • Co-author of 27 publications with the Minor Lab  (cited 647 times) .
  • Co-author of 60 structures with the Minor Lab [show]
  • Relative Citation Ratio (RCR): 27.88

  • Training Period: 2003-07 PhD2007-11 Postdoc2011-2015 Instructor
  • Prior Institution: Juniata College, PA
  • Prior Degree: BSc, PhD (1998)
  • Project Title: The Xtaldb crystallization expert system and its application to the structure of the 5'-nucleotidase YfbR
  • Current Position: CCRi (Commonwealth Computer Research, Inc), Charlottesville, VA

Publications with the Minor Lab

  1. Grabowski M, Langner KM, Cymborowski M, Porebski PJ, Sroka P, Zheng H, Cooper DR, Zimmerman MD, Elsliger MA, Burley SK, Minor W (2016)
    A public database of macromolecular diffraction experiments.
    Acta Crystallogr D Struct Biol 72: 1181-1193 Times cited: 13 [Pub Med ID: 27841751] [Pub Med Central ID: PMC5108346]
  2. Grabowski M, Niedzialkowska E, Zimmerman MD, Minor W (2016)
    The impact of structural genomics: the first quindecennial.
    J. Struct. Funct. Genomics 17: 1-16 Times cited: 11 [Pub Med ID: 26935210] [Pub Med Central ID: PMC4834271]
    F-1000 Recommended Publication
  3. Hou J, Zheng H, Chruszcz M, Zimmerman MD, Shumilin IA, Osinski T, Demas M, Grimshaw S, Minor W (2015)
    Dissecting the Structural Elements for the Activation of β-Ketoacyl-(Acyl Carrier Protein) Reductase from Vibrio cholerae.
    J. Bacteriol. 198: 463-76 Times cited: 4 [Pub Med ID: 26553852] [Pub Med Central ID: PMC4719456]
  4. Berman HM, Gabanyi MJ, Groom CR, Johnson JE, Murshudov GN, Nicholls RA, Reddy V, Schwede T, Zimmerman MD, Westbrook J, Minor W (2015)
    Data to knowledge: how to get meaning from your result.
    IUCrJ 2: 45-58 Times cited: 6 [Pub Med ID: 25610627] [Pub Med Central ID: PMC4285880]
  5. Zheng H, Handing KB, Zimmerman MD, Shabalin IG, Almo SC, Minor W (2015)
    X-ray crystallography over the past decade for novel drug discovery - where are we heading next?
    Expert Opin Drug Discov 10: 975-89 Times cited: 16 [Pub Med ID: 26177814] [Pub Med Central ID: PMC4655606]
  6. Zheng H, Hou J, Zimmerman MD, Wlodawer A, Minor W (2014)
    The future of crystallography in drug discovery.
    Expert Opin Drug Discov 9: 125-37 Times cited: 14 [Pub Med ID: 24372145] [Pub Med Central ID: PMC4106240]
  7. Zimmerman MD, Grabowski M, Domagalski MJ, Maclean EM, Chruszcz M, Minor W (2014)
    Data management in the modern structural biology and biomedical research environment.
    Methods Mol. Biol. 1140: 1-25 Times cited: 12 [Pub Med ID: 24590705] [Pub Med Central ID: PMC4086192]
  8. Domagalski MJ, Zheng H, Zimmerman MD, Dauter Z, Wlodawer A, Minor W (2014)
    The quality and validation of structures from structural genomics.
    Methods Mol. Biol. 1091: 297-314 Times cited: 9 [Pub Med ID: 24203341] [Pub Med Central ID: PMC4081469]
  9. Gront D, Grabowski M, Zimmerman MD, Raynor J, Tkaczuk KL, Minor W (2012)
    Assessing the accuracy of template-based structure prediction metaservers by comparison with structural genomics structures.
    J. Struct. Funct. Genomics 13: 213-25 Times cited: 6 [Pub Med ID: 23086054] [Pub Med Central ID: PMC4105012]
  10. Majorek KA, Porebski PJ, Dayal A, Zimmerman MD, Jablonska K, Stewart AJ, Chruszcz M, Minor W (2012)
    Structural and immunologic characterization of bovine, horse, and rabbit serum albumins.
    Mol. Immunol. 52: 174-82 Times cited: 213 [Pub Med ID: 22677715] [Pub Med Central ID: PMC3401331]
  11. Klimecka MM, Chruszcz M, Font J, Skarina T, Shumilin I, Onopryienko O, Porebski PJ, Cymborowski M, Zimmerman MD, Hasseman J, Glomski IJ, Lebioda L, Savchenko A, Edwards A, Minor W (2011)
    Structural analysis of a putative aminoglycoside N-acetyltransferase from Bacillus anthracis.
    J. Mol. Biol. 410: 411-23 Times cited: 8 [Pub Med ID: 21601576] [Pub Med Central ID: PMC3131501]
  12. Gabanyi MJ, Adams PD, Arnold K, Bordoli L, Carter LG, Flippen-Andersen J, Gifford L, Haas J, Kouranov A, McLaughlin WA, Micallef DI, Minor W, Shah R, Schwede T, Tao YP, Westbrook JD, Zimmerman M, Berman HM (2011)
    The Structural Biology Knowledgebase: a portal to protein structures, sequences, functions, and methods.
    J. Struct. Funct. Genomics 12: 45-54 Times cited: 39 [Pub Med ID: 21472436] [Pub Med Central ID: PMC3123456]
  13. Cymborowski M, Klimecka M, Chruszcz M, Zimmerman MD, Shumilin IA, Borek D, Lazarski K, Joachimiak A, Otwinowski Z, Anderson W, Minor W (2010)
    To automate or not to automate: this is the question.
    J. Struct. Funct. Genomics 11: 211-21 Times cited: 18 [Pub Med ID: 20526815] [Pub Med Central ID: PMC2921494]
  14. Sledź P, Kamiński R, Chruszcz M, Zimmerman MD, Minor W, Woźniak K (2010)
    An experimental charge density of HEPES.
    Acta Crystallogr., B 66: 482-92 Times cited: 9 [Pub Med ID: 20631430]
  15. Sledz P, Zheng H, Murzyn K, Chruszcz M, Zimmerman MD, Chordia MD, Joachimiak A, Minor W (2010)
    New surface contacts formed upon reductive lysine methylation: improving the probability of protein crystallization.
    Protein Sci. 19: 1395-404 Times cited: 22 [Pub Med ID: 20506323] [Pub Med Central ID: PMC2974831]
  16. Luo HB, Zheng H, Zimmerman MD, Chruszcz M, Skarina T, Egorova O, Savchenko A, Edwards AM, Minor W (2010)
    Crystal structure and molecular modeling study of N-carbamoylsarcosine amidase Ta0454 from Thermoplasma acidophilum.
    J. Struct. Biol. 169: 304-11 Times cited: 12 [Pub Med ID: 19932181] [Pub Med Central ID: PMC2830209]
  17. Koclega KD, Chruszcz M, Zimmerman MD, Bujacz G, Minor W (2009)
    'Hot' macromolecular crystals.
    Cryst Growth Des 10: 580 Times cited: 3 [Pub Med ID: 20161694] [Pub Med Central ID: PMC2809425]
  18. Wang S, Kirillova O, Chruszcz M, Gront D, Zimmerman MD, Cymborowski MT, Shumilin IA, Skarina T, Gorodichtchenskaia E, Savchenko A, Edwards AM, Minor W (2009)
    The crystal structure of the AF2331 protein from Archaeoglobus fulgidus DSM 4304 forms an unusual interdigitated dimer with a new type of alpha + beta fold.
    Protein Sci. 18: 2410-9 Times cited: 2 [Pub Med ID: 19768810] [Pub Med Central ID: PMC2788295]
  19. Grabowski M, Chruszcz M, Zimmerman MD, Kirillova O, Minor W (2009)
    Benefits of structural genomics for drug discovery research.
    Infect Disord Drug Targets 9: 459-74 Times cited: 23 [Pub Med ID: 19594422] [Pub Med Central ID: PMC2866842]
  20. Chruszcz M, Zimmerman MD, Wang S, Koclega KD, Zheng H, Evdokimova E, Kudritska M, Cymborowski M, Savchenko A, Edwards A, Minor W (2008)
    Function-biased choice of additives for optimization of protein crystallization - the case of the putative thioesterase PA5185 from Pseudomonas aeruginosa PAO1.
    Cryst Growth Des 8: 4054-4061 Times cited: 2 [Pub Med ID: 19898606] [Pub Med Central ID: PMC2700756]
  21. Beloglazova N, Brown G, Zimmerman MD, Proudfoot M, Makarova KS, Kudritska M, Kochinyan S, Wang S, Chruszcz M, Minor W, Koonin EV, Edwards AM, Savchenko A, Yakunin AF (2008)
    A novel family of sequence-specific endoribonucleases associated with the clustered regularly interspaced short palindromic repeats.
    J. Biol. Chem. 283: 20361-71 Times cited: 117 [Pub Med ID: 18482976] [Pub Med Central ID: PMC2459268]
  22. Zimmerman MD, Proudfoot M, Yakunin A, Minor W (2008)
    Structural insight into the mechanism of substrate specificity and catalytic activity of an HD-domain phosphohydrolase: the 5'-deoxyribonucleotidase YfbR from Escherichia coli.
    J. Mol. Biol. 378: 215-26 Times cited: 43 [Pub Med ID: 18353368] [Pub Med Central ID: PMC2504004]
  23. Chruszcz M, Potrzebowski W, Zimmerman MD, Grabowski M, Zheng H, Lasota P, Minor W (2008)
    Analysis of solvent content and oligomeric states in protein crystals--does symmetry matter?
    Protein Sci. 17: 623-32 Times cited: 24 [Pub Med ID: 18359856] [Pub Med Central ID: PMC2271157]
  24. Koclega KD, Chruszcz M, Zimmerman MD, Cymborowski M, Evdokimova E, Minor W (2007)
    Crystal structure of a transcriptional regulator TM1030 from Thermotoga maritima solved by an unusual MAD experiment.
    J. Struct. Biol. 159: 424-32 Times cited: 7 [Pub Med ID: 17588774] [Pub Med Central ID: PMC2093942]
  25. Petkowski JJ, Chruszcz M, Zimmerman MD, Zheng H, Skarina T, Onopriyenko O, Cymborowski MT, Koclega KD, Savchenko A, Edwards A, Minor W (2007)
    Crystal structures of TM0549 and NE1324--two orthologs of E. coli AHAS isozyme III small regulatory subunit.
    Protein Sci. 16: 1360-7 Times cited: 13 [Pub Med ID: 17586771] [Pub Med Central ID: PMC2206681]
  26. Doyle CR, Zimmerman MD, Chruszcz M, Cymborowski M, Gawlicka-Chruszcz A, Minor W (2006)
    Crystal structure of 6-(4-difluoromethoxy-3-methoxyphenyl)-3(2H)-pyridazinone,C12H10F2N2O3.
    Zeitschrift fur Kristallographie 221: 359-360
  27. Zimmerman MD, Chruszcz M, Cymborowski M, Zheng HP, Minor W (2006)
    Disodium 4-nitrophenylphosphate hexahydrate.
    Acta Crystallogr Sect E Struct Rep Online 62: M884-M886 Times cited: 1